Single-Source from the Reader's Point of View
Documentation written for single-sourcing (topic based, like that found in DITA) has great potential for efficiency. Writing once and publishing in many publications (Developer Guides, User Guides, etc.) and many formats (pdf, html, HTMLHelp, etc.) turns into cost and time savings. However, these efficiencies can cause inefficiencies for the users. Many online help users complain they cannot find the information they need while using the search function. Readers are more likely to comprehend texts with a classical book architecture, an architecture which is often sacrificed in single sourced documents and online Help files. When texts are cohesive, readers are more likely to consider information to be clear, well organized and easy to follow. For comprehensibility, it is essential to have a manual review, even when composing is partially automated.
Mulvihill, Teresa. LiveTechDocs (2008). Articles>Content Management>Single Sourcing>Audience Analysis