Recently, I was surprised to learn that about 8 percent of men and 0.5 percent of women have some form of color blindness. For some Web sites that could translate to 1 in 12 visitors. That's a larger proportion of visitors than some other groups I consider when designing Web sites. The ratio of visitors viewing the Web with only 256 colors or a 640x480 pixel screen is usually less than 5 percent these days. Now include cross-browser support, older browsers, style sheets, and JavaScript in the mix. If you consider those issues when you design Web sites, you should consider your color-blind visitors, as well.
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